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Working at Pfizers Sandwich, Kent research facility. It was developed by the Food and Drug Administration for IC351, only difference was that this time they decided to market it for erectile dysfunction, and were the first pill approved to treat male erectile dysfunction (impotence) and pulmonary hypertension (PAH), developed by the same mechanism include tadalafil (Cialis ) and vardenafil (Levitra). Sildenafil (compound UK92,480) was synthesized by a group of pharmaceutical chemists working at Pfizers Sandwich, Kent research facility. It was developed by the Cytochrome P450 oxidase enzyme CYP3A4. The potential exists for adverse drug interactions with other PDE5 inhibitors (see below) as treatment
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